Evolution of bilaterian central nervous systems: a single origin?

Abbreviations
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ANR: Anterior neural ridge; A/P: Anterior/posterior; BMP: Bone morphogenetic protein; CNS: Central nervous system; D/V: Dorso/ventral; ISO: Isthmic organizer; MHB: Midbrain/hindbrain boundary; ZLI: Zona limitans intrathalamica.

Authors’ contributions
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LZH coordinated and wrote much of the manuscript. MS, HE, SMS, JKY and VL contributed to writing the manuscript. JEC and MS prepared the figures. All authors read and approved the final manuscript.

Acknowledgements
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The authors thank Peter WH Holland, ND Holland and Nacho Maeso for critically reading the manuscript and for useful suggestions. JKY was supported by the National Science Council, Taiwan (NSC99-2627-B-001-003, NSC101-2923-B-001-004-MY2), and by the Career Development Award from Academia Sinica, Taiwan (AS-98-CDA-L06). MS was supported by funds from the ANR (ANR-09-BLAN-0262-02 and ANR-11-JSV2-002-01), CNRS and UPMC.